姓名：张立

性别：男

职称：副教授

学位：博士

专业：分析化学

电子邮箱：zhangli8@ncu.edu.cn

研究方向：纳米材料制备、调控及生物/环境分析

电话：15070090148

教育经历：

2005.9-2010.6 西南大学 博士 导师：黄承志教授

2001.9-2005.7 西南师范大学 本科

工作经历：

2014.12-至今 南昌大学 副教授

2018.8-2019.8 纽约州立大学布法罗分校 访问学者

2010.7-2014.12 南昌大学 讲师

科研简介：

主要研究方向为无机及有机纳米材料制备、修饰及其生化/环境分析应用。从事不同形态、光电性能各异的金属纳米材料（如金、银、钼、稀土等）、碳纳米材料（如石墨烯、石墨烯量子点等）及共价有机框架材料（COF）的合成及修饰，在此基础上开拓上述材料在离子检测、生物传感、疾病诊断、细胞成像及药物治疗等领域的分析应用。主持两项国家自然科学基金项目、一项江西省杰出青年基金项目、两项江西省自然科学基金项目及一项江西省教育厅基金项目。以第一作者或通讯作者身份在国际知名期刊Anal. Chem., Small, Chem. Commun., Chem. Eur. J., Biosens. Bioelectron., ACS Appl. Mater. Interfaces, TrAC Trends Anal. Chem.等发表SCI论文三十余篇。

主持科研项目:

1、国家自然科学基金项目：荧光共价有机骨架的制备及其在金属离子分析中的应用研究（21964011）。

2、国家自然科学基金项目：石墨烯量子点光致发光性质在核酸类分子及蛋白质分析中的应用研究（21105044）。

3、江西省杰出青年基金项目：基于多巴胺印迹纳米材料的重金属离子同时检测和去除（2018ACB21008)。

4、江西省自然科学基金项目：DNA荧光量子点在磷酸酶活性分析及抑制剂药物筛选中的应用研究（20171BAB203016）。

5、江西省自然科学基金项目：石墨烯量子点制备及其发光特性在生化分析和细胞成像中的应用研究（20114BAB213013）。

6、江西省教育厅科技计划项目：荧光银纳米簇在疾病相关DNA及DNA修饰酶分析中的应用研究（GJJ14119）。

社会兼职：

1、《分析试验室》青年编委。

获奖情况：

1. 功能化石墨烯的电催化和分析化学研究，江西省自然科学奖二等奖，江西省人民政府，2018年度，排名第二；

2. 光散射纳米探针及其分析应用，重庆市自然科学奖一等奖，重庆市人民政府，2013年度，排名第四；

3. 纳米组装体的可控制备及其在细胞成像分析中的应用研究，重庆市优秀博士学位论文，重庆市教委，2011年，完成者。

发表论文：

1. Li Zhang#, Zhi-Yi Zhang#, Ru-Ping Liang, Ya-Hua Li, Jian-Ding Qiu*. Boron-doped graphene quantum dots for selective glucose sensing based on the “abnormal” aggregation-induced photoluminescence enhancement, Analytical Chemistry, 2014, 86, 4423-4430. (IF=6.785, ESI Top 1%, Nature Index)

2. Li Zhang, Wei Song, Ru-Ping Liang, Jian-Ding Qiu*, Simultaneous determination of protein kinase A and casein kinase II by dual-color peptide biomineralized metal nanoclusters, Analytical Chemistry, 2016, 88, 11460-11467. (IF=6.785, Nature Index)

3. Li Zhang, Dong Peng, Ru-Ping Liang, Jian-Ding Qiu*. Nitrogen-doped graphene quantum dots as a new catalyst accelerating the coordination reaction between Cadmium(II) and 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin for Cadmium(II) sensing, Analytical Chemistry, 2015, 87, 10894-10901. (IF=6.785, Nature Index)

4. Li Zhang, Huanjun Chen, Jianfang Wang, Yuan Fang Li, Jian Wang, You Sang, Sai Jin Xiao, Lei Zhan, Cheng Zhi Huang*. Tetrakis(4-sulfonatophenyl)porphyrin-directed assembly of gold nanocrystals: Tailoring the plasmon coupling through controllable gap distances, Small, 2010, 6, 2001-2009. (Highlighted as Frontispiece, IF=11.459)

5. Sai Jin Xiao, Xiao Jing Zhao, Ping Ping Hu, Zhao Jun Chu, Cheng Zhi Huang, Li Zhang*. Highly photoluminescent molybdenum oxide quantum dots: One-pot synthesis and application in 2,4,6-trinitrotoluene determination, ACS Applied Materials & Interfaces, 2016, 8, 8184-8191. (IF=8.758)

6. Li Zhang, Shu Jun Zhen, You Sang, Jing Yun Li, Yi Wang, Lei Zhan, Li Peng, Jian Wang, Yuan Fang Li, Cheng Zhi Huang*. Controllable preparation of metal nanoparticle/carbon nanotube hybrids as efficient dark field light scattering agents for cell imaging, Chemical Communications, 2010, 46, 4303-4305. (IF=5.996, Nature Index)

7. Li Zhang, Xiao-Rong Chen, Shao-Hua Wen, Ru-Ping Liang, Jian-Ding Qiu*. Optical sensors for inorganic arsenic detection, TrAC-Trends in Analytical Chemistry, 2019, 118, 869-879. (IF=9.801)

8. Li Zhang, Dong Peng, Ru-Ping Liang, Jian-Ding Qiu*. Graphene-based optical nanosensors for detection of heavy metal ions, TrAC-Trends in Analytical Chemistry, 2018, 102, 280-289. (IF=9.801)

9. Li Zhang#, Xiu-Zhi Cheng#, LanKuang, Ai-Zhen Xu, Ru-Ping Liang, Jian-Ding Qiu#*, Simple and highly selective detection of arsenite based on the assembly induced fluorescence enhancement of DNA quantum dots, Biosensors and Bioelectronics，2017, 94, 701-706. (IF=10.257)

10. Li Zhang, Dong Peng, Ru-Ping Liang, Jian-Ding Qiu*. Graphene quantum dots assembled with metalloporphyrins for “turn on” sensing of hydrogen peroxide and glucose, Chemistry-A European Journal, 2015, 21, 9343-9348. (IF=4.857)

11. Sai Jin Xiao, Jun Zuo, Zhi Qiang Zhu, Yong Zhong Ouyang, Xing Lei Zhang, Huan Wen Chen, Li Zhang*. Highly sensitive DNAzyme sensor for selective detection of trace uranium in ore and natural water samples, Sensors and Actuators B: Chemical, 2015, 210, 656-660. (IF=7.100)

12. Li Zhang, Ming-Fang Hong, Jie Peng, Jia-Qing Chen, Ru-Ping Liang, Jian-Ding Qiu*. A sensitive assay of telomerase activity based on the controllable aggregation of quantum dots, Sensors & Actuators: B. Chemical, 2018, 277, 22-29. (IF=7.100)

13. Ting-Xiang Liu#, Li Zhang#, Ru-Ping Liang∗, Jian-Ding Qiu∗. Highly selective detection of disulfenylated proteins through adimedone-based fluorescent probe and application in cells, Sensors & Actuators: B. Chemical, 2017, 238, 257-263. (IF=7.100)

14. Li Zhang, Zhao-Wu Wang, Sai-Jin Xiao, Dong Peng, Jia-Qing Chen, Ru-Ping Liang, Jun Jiang*. Jian-Ding Qiu*, Fluorescent molybdenum oxide quantum dots and HgII synergistically accelerate cobalt porphyrin formation: a new strategy for trace HgII analysis, ACS Applied Nano Materials, 2018, 1, 1484-1491.

15. Sai Jin Xiao, Xiao Jing Zhao, Jun Zuo, Hai Qing Huang, Li Zhang*. Highly photoluminescent MoOx quantum dots: Facile synthesis and application in off-on Pi sensing in lake water samples, Analytica Chimica Acta, 2016, 906, 148-155. (IF=5.977)

16. Li Zhang, Ming-Fang Hong, Jia-Qing Chen, Jie Peng, Ru-Ping Liang, Jian-Ding Qiu*. Regulation of multiple energy transfer processes in a simple nanosystem for sensitive telomerase detection, Analytica Chimica Acta, 2020, 1097, 135-143. (IF=5.977)

17. Li Zhang, Jie Peng, Ming-Fang Hong, Jia-Qing Chen, Ru-Ping Liang, Jian-Ding Qiu*. A facile graphene oxide-based fluorescent nanosensor for the in situ “turn-on” detection of telomerase activity, Analyst, 2018, 143, 2334-2341. (IF=3.978)

18. Li Zhang, Jia-Qing Chen, Ming-Fang Hong, Ru-Ping Liang, Jian-Ding Qiu*. Facile synthesis of fluorescent tungsten oxide quantum dots for telomerase detection based on the inner filter effect, Analyst, 2020, 145, 2570-2579. (IF=3.978)

19. Li Zhang, Jie Peng, Ming-Fang Hong, Jia-Qing Chen, Ru-Ping Liang, Jian-Ding Qiu*. Cobalt phosphide nanowires for fluorometric detection and in-situ imaging of telomerase activity via hybridization chain reactions, Microchimica Acta, 2019, 186, 309. (IF=6.232)

20. Li Zhang, Sai Jin Xiao, Lin Ling Zheng, Yuan Fang Li, Cheng Zhi Huang*. Aptamer-mediated nanocomposites of semiconductor quantum dots and graphene oxide as well as their applications in intracellular imaging and targeted drug delivery, Journal of Materials Chemistry B, 2014, 2, 8558-8565. (IF=5.344)

21. Li Zhang, Ru-Ping Liang, Sai-Jin Xiao, Jian-Mei Bai, Lin-Ling Zheng, Lei Zhan, Xi-Juan Zhao, Jian-Ding Qiu*, Cheng-Zhi Huang*. DNA-templated Ag nanoclusters as fluorescent probes for sensing and intracellular imaging of hydroxyl radicals, Talanta, 2014, 118,339-347. (IF=5.339)

22. Li Zhang, Yun-Mei Zhang, Ru-Ping Liang, Zhong-Xia Wang, Jian-Ding Qiu*. Colorimetric logic gates based on ion-dependent DNAzymes, The Journal of Physical Chemistry C, 2013, 117, 12352-12357. (IF=4.189)

23. Li Zhang, Cheng Zhi Huang*, Yuan Fang Li, Qing Li. Morphology control and structural characterization of Au crystals: From twinned tabular crystals and single-crystalline nanoplates to multitwinned decahedra, Crystal Growth & Design, 2009, 9, 3211-3217. (IF=4.089)

24. Li Zhang, Zhong-Xia Wang, Ru-Ping Liang, Jian-Ding Qiu*. Easy design of colorimetric logic gates based on nonnatural base pairing and controlled assembly of gold nanoparticles, Langmuir, 2013, 29, 8929-8935. (IF=3.557)

25. Li Zhang, Ming Fang Hong, Zhao Jun Chu, Han Xu, Shan Ping Wang, Xiao Jing Zhao, Sai Jin Xiao*. A new copper mediated on-off assay for alkaline phosphatase detection based on MoOx quantum dots, Microchemical Journal, 2018, 141, 170-175. (IF=3.594)

26. Li Zhang, Cheng Zhi Huang*, Yuan Fang Li, Sai Jin Xiao, Jian Ping Xie. Label-free detection of sequence-specific DNA with multiwalled carbon nanotubes and their light scattering signals, Journal of Physical Chemistry B, 2008, 112, 7120-7122. (IF=2.857)

27. Sai Jin Xiao, Xiao Jing Zhao, Zhao Jun Chu, Han Xu, Guo Qing Liu, Cheng Zhi Huang, Li Zhang*, New off–on sensor for captopril sensing based on photoluminescent MoOx quantum dots, ACS Omega, 2017, 2, 1666-1671. (IF=2.870)

28. Sai Jin Xiao, Zhao Jun Chu, Jun Zuo, Xiao Jing Zhao, Cheng Zhi Huang, Li Zhang*, Fluorescent carbon dots: facile synthesis at room temperature and its application for Fe2+ sensing, Journal of Nanoparticle Research, 2017, 19, 84. (IF=2.132)

29. Sai Jin Xiao, Li Zhi Wang, Ming Yue Yuan, Xiao Huan Huang, Jian Hua Ding*, Li Zhang*. Peroxidase-mimetic and fenton-like activities of molybdenum oxide quantum dots, ChemistrySelect, 2020, 5, 10149-10155. (IF=1.811)

30. Li Zhang, Li-Xia Fan, Ru-Ping Liang*, Jian-Ding Qiu*.Construction of biomimetic interface by layer-by-layer self-assembly technique for electrochemical amperometric immunosensing applications, Chinese Journal of Analytical Chemistry, 2013, 41, 1795-1800. (IF=0.936)

31. Sai Jin Xiao, Jun Zuo, Xiao Feng Dong, Xiao Jing Zhao, Li Zhang*. Label-free and rapid detection of histidine-rich peptides in Saliva, Spectroscopy and Spectral Analysis, 2016, 36, 2906-2910. (IF=0.452)

专利：

1、 邱建丁；王莹；张立；梁汝萍，基于金纳米粒子-多肽团聚效应的蛋白激酶及其抑制剂检测方法，发明专利，中国，专利号：ZL201410196470.X，授权日期：2016-08-17；

2、 邱建丁；张慧；张立；梁汝萍，基于石墨烯量子点的类过氧化物酶催化特性的葡萄糖检测方法，发明专利，中国，专利号：ZL201410202591.0，授权日期：2017-06-30；

3、 肖赛金；张立；徐函；王礼治; 丁健桦; 徐丽，一种类芬顿试剂及其制备方法和应用，发明专利，中国，申请号：201910827967X，日期：2019.9.3。